Hyalogen C + Apro (30 sachets / 4.4 gr)


Enjoyable taste with apple / orange / carrot juice. Suitable for diabetics. It contains stevia

Hyalogen C+Apro – Bioactive Collagen of High Bioavailability

“Active ingredients: Bioactive collagen”

Bioactive collagen-enhanced with the effects of vitamin C + provitamin A, chondroitin and organic extracts of pomegranate, grape & stevia. Collagen is a protein that is consisted at 45% of the weight of a normal person and is responsible for the construction of all the basic body structures, such as tendons, heart, nails, hair, skin, gums, eyes, joints and blood vessels. After the age of 30, the production of collagen decreases by 1-1.5% per year and this has obvious effects on the skin where the first signs of aging appear, thereafter it significantly affects our health, thus the quality of our lives.

THE No.1 Collagen With Nutritional Value
You don’t have to appear old aged anymore!

Win the battle against time with a collagen which has the highest proven anti-aging effects. Clinical studies showed that it is important not only to drink the collagen, but to drink it by using the most absorbable and usable form which is ideally combined with other active ingredients.


The reason why … not all collagens are the same!

The HYALOGEN C + A pro, due to the combination of selected ingredients therein, is a juice with multiple actions. The most impressive effect by combining collagen with pomegranate & grape extract is the reduction of wrinkle depth. Just collagen alone, can cause a reduction of  26% and by combining it with chondroitin can cause a reduction of 13.2%, (28) The unique combination of pomegranate & grape which is contained in HYALOGEN C + Apro reduces the depth of wrinkles by 82%. (34) The final result of the two ingredients above is that pomegranate reduces the symptoms of osteoarthritis(37) and rheumatoid arthritis. (38) due to pomegranate’s effect on the cartilage.(38)

The studied cocktail of combined actions of HYALOGEN C + A pro prove its worth by slowing aging process and providing multiple benefits for juvenileness:

  • Reduction of the wrinkles’ depth by 82% (collagen, pomegranate, grape)
  • Reduction of osteoarthritis symptoms (collagen, pomegranate, chondroitin).
  • Reduction of rheumatoid arthritis symptoms (pomegranate).
  • Increase of skin moisture and reduction of dryness (collagen, pomegranate, grape, chondroitin).
  • Reduction of fine wrinkles (collagen, chondroitin, pomegranate, grape).
  • Increase of skin’s elasticity (collagen, pomegranate, grape).
  • Reduction of brown spots (pomegranate, grape).
  • During its consumption it maintains the effects of vitamins A and C, (instantaneous dissolution due to the powder form).
  • Safe for renal function


– Valid scientific studies demonstrated that a daily dose of 5gr collagen (which is contained in HYALOGEN + Apro) has a preventive, beneficial therapeutic effect.

– It is a juice of hydrolyzed collagen with low molecular weight (<3000 D) which has excellent organoleptic properties and instantaneous solubility, with apple, orange and carrot flavor.

– The only juice which combines collagen with other useful components for the body, such as pomegranate and grape extract, the amazingly active chondroitin, and vitamins A (beta-carotene) and C (ascorbic acid) at a dosage that was resulted from clinical studies .

– The combination of  HYALOGEN C + A pro active ingredients increases the anti-aging effect on the skin and has a catalytically beneficial effect on cartilage bone, conclusions which are supported by clinical studies. Specifically, the intake of hydrolyzed collagen combined with chondroitin, it was stated that reduces dryness by 76%, while at the same time it increases the collagen content of the skin by 6%. (28)

– The consumption of  the same composition (hydrolyzed collagen – chondroitin) at a larger daily dose for 10 weeks reduced pain symptoms which were caused by osteoarthritis, showing a statistically significant difference when were compared with those who had not taken the particular composition. (29) The outcome from this combination is more evident than from the composition with chondroitin (10 weeks) (30) and faster than the outcome of the usual combination with chondroitin – glucosamine – quercetin, wherein the pain reduction effect was realized after 12 and 16 weeks. (31, 32)

– Also, chondroitin inhibits hyaluronidase enzyme which is responsible for the reduction of hyaluronic acid in the synovial fluid. (33)

– The addition of pomegranate extract (anthocyanins and polyphenols) and red grape extract (proanthocyanidins and resveratrol), offers an additional effect, besides increasing the humidity and elasticity of the skin (21, 31),they decrease the color of brown spots (freckles). (34)

– Fythermore, the components which are contained in pomegranate extract (anthocyanins) inhibit the enzyme responsible for the destruction of skin collagen thereby increasing the content of collage, while at the same time cause the renewal of skin(35, 36) and protect against photoaging.(37)


Apple / Carrot / Orange Flavoured

Ingredients: Hydrolyzed collagen, fruit extract (pomegranate, grape, orange), acidifying agent: citric acid, malic acid, Sweeteners [steviol glycosides (extract of the stevia plant)] Aroma (apple, carrot), Antioxidant vitamins: ascorbic beta-carotene, chondroitin

Dosage: 1-2 sachets in 100ml of water daily.

It Gives 5,04gr of collagen per 100ml of drink (1/2 cup), Vitamin C, Provitamin A.


Natural Formula:
No Sugar / No Iodine / No Gluten /No Preservatives / No Starch / No Lactose
No Artificial Colors & Fragrances / No Yeast / No Salt

Suitable for diabetics / With Stevia

  1. SATO,N., YSHINAKA,R., ITOH,Y., SATO,M., 1989. Comp. Biochem. Physiolo. 92B, 87-91
  2. ZYLBERBERG, D.J., BONAVENTURE, J., CHOEN-SOLAL, L., HARTMAN, D.I., BEREITERAHN, J. 1992. Jcell sci 103, 273-285
  3. BARON, E., BIONDO-SIMOES, M., AUERSVALD, A., AUERSVALD, L., NETTO, M., ORTOLAN, M., KOHLER, J. 2012. Acta. Cir. Bras vol27 no10
  4. LI, X., REZAEI, R., WU, E., 2011. Amino Acids 40(4):1 159-68
  5. KAWAHARA, K., NISHI, Y., NAKAMURA, S., UZHIYAMA, S., NISHIUCHI, Y., NAKAZAWA, T., OHKUTO, T., KOBAYASHI, Y., Biochem 2005. 6;44(48):15212-22
  6. IWAI, K., HASEGAWA, T., TAGUCHI, Y., MORIMATSU, F., SATO, K., NAKAMURA, Y., HICASH, A., KIDO, Y., NAKABO, Y., OHTSUKI, K. 2005. J. Agric. Food Chem., 3, 6531-37
  7. OHARA, H., MATSUMOTO, H., ITO, K., IWAI, K., SATO, K., 2007. J. Agric. Food Chem. 55, 1532-35
  8. SATO, K., IWAI, K., AITO-INOVE, M., 2008. J. Aoac. Inter. Vo1 91 No4
  9. SUGIHARA, F., INOVE, N., KUWAMORI, M., TANEUCHI, M. 2012. J. Biosci. Bioeng. 113(2): 202-3
  10. AITO-INOVE, M., LACKEYRAM, D., FAN, MZ., SATO, K., MINE, Y., 2007. J. Pept. Sci 13(7):468-74
  11. KAWAGUCHI, T., NANBU, PN., KUROKAWA, M., 2012. Biol. Pharm. Ball. 35(3):422-7
  12. WATANABE-KAMIYAMA, M., SHIMIZU, M., KAMIYAMA, S., TACUCHI, Y., SONE, H., MOKIMATSU, F., SCHIRAKAWA, H., FURUKAWA, Y., KOMAI, M., 2010. J. Agric. Food Chem. 27;58(2):835-41
  13. SHICEMURA, Y., IWAI, K., MORIMATSU, F., IWAMOTO, T., MOKI, T., ODA, C., TAIRA, T., PARK, E., NAKAMURA, Y., SATO, K., 2009. J. Agric. Food Chem. 28;57(2) 444-9
  14. OHARA, H., ICHIKAWA, S., MATSUMOTO, H., AKIYAMA, M., FUJIMOTO, N., KOMAYASHI, T., TAJIMA, S., 2010. J. Derm. 37(4):330-8
  15. OHARA, H., IIDA, H., ITO, K., TAKEUCHI, Y., NOMURA, Y., 2010. Biosci. Bioctechnol. Biochem 74(10):2096-9
  16. NAKATAVI, S., MANO, H., SAMQEI, C., SHIMIZU, J., WADA, M., 2009. Osteoarthritis Cartilage 17(12):1620-7
  17. BAUCHRT, C., MORZEL, M., CHAMBON, E., MIRAND, P., REYNES, C., BUFFIERE, C., REMOND, D., 2007. Br. J. Nutr. 98(6):1187-95
  18. ESCUPERO, E., SENTANDREU, M.A., TOLDRA, F., 2010. J. Agric. Food Chem. 58:5160-65
  19. MESSIA, MC., MARCONI, E., 2012. Methods of Biol. 828:281-9
  20. OBA, C., OHARA, H., MORIFUJI, M., ITO, K., ICHIKAWA, S., KAWAHATA, K., KOGA, J., 2013. Photod. Photoimn. Photomed. 29(4):204-11
  21. PROKSCH, E., SEGGER, D., DEGWERT, J., SCHUNCK, M., ZAGUE, V., OESSER, S., 2014 Skin Pharm. Physiol. 27(1):45-55
  22. KOYAMA, Y., 2009. Shokuhinto Kaihatsu 44:10-12
  23. MATSUMOTO, H., OHARA, H., ITOH, K., NAKAMURA, Y., TAKAHASHI, S., 2006. ITE Lett. 7:386-90
  24. BELLO, AE., OESSER, S., Curr. Med. Res. Opin. 2006. 22(11):2221-32
  26. GUILLERMINET, F., BEAUDIED, H., FABIEN-SOULE, V., TOME, D., BENHAMON, GL., ROUX, C., BLAIS, A., 2009. Bone xxx xxx-xxx
  27. LEEM, KH., LEE, S., JANE, A., KIM, HK., 2013. J. Med. Food 16(5):447-53
  28. SCHWARTZ, S., PARK, J., 2012. J. Clin. Interv. Aging 7:267-73
  29. SCHAUSS, AG., STENEHJEM, J., PARK, J., ENDRES, JP., CLEWEEL, A., 2012. J. Agric. Food Chem. 25;60(16)4096-101
  30. MAZIERES, B., HUCHER, M., ZAIM, M., GANERO, P., 2007. Ann. Rheum. Dis. 66(5):639-45
  31. MATSUNO, H., NAKAMURA, H., KATAYAMA, K., HAYASHI, S., KANO, S., YODOH, K., KISO, Y., 2009. Biotechnol. Biochem. 73(2)288-292
  32. KANZAKI, N., SAITO, K., MAEDA, A., KITAWAGA, Y., KISO, Y., WATANABE, K., TOMONAGA, A., NAGAOKA, I., YAMAGUCHI, H., 2012. J. sci Food Agric. 15:92(4):862-9
  34. BUONOCORE, D., LAZZERETTI, A., TOCABENS, P., NOBILE, V., CESTONE, E., SANTIN, E., BOTTONE, M., MARZATICO, F., 2012. Clin. Cosmet. Invest. Derm. 5:159-165
  35. CHAMCHCU, JC., AFAG, F., SUED, DN., SIDDIQUI, ADHAMI, VM., KHAN, N., SINEH, S., BOYLAN, BT., WOOD, GS., MUKHTAR, H., 2013. Exp. Derm. 22(5):342-8
  36. LIM, TG., JUNES, K., KIM, JE., KIM, Y., LEE, H.J., JANG, TS., LEE, KW., Exp. Dermatol. 2013. 22(6):428-30
  37. PARK, HM., MOON, E., KIM, AJ., LEE, S., LEE, JB., PARK, Y.K., JUNG, HS., KIM, YB., KIM, SY., 2010. Int. J. Dermatol. 49(3):276-82
  38. JEAN-GILLES, D., LI, L., VAIDYANATHAN, VG., KING, R., CHO, B., WORTHEN, DR., CHICHESTER, C., SEERAM, NA., 2013. Chem. Biol. Interact 25;205(2):90-9
  39. HASEEB, A., CHEN, D., HAGGIT, M., 2013. Rheumatology 52(6):998-1008
  40. SHEN, CL., SMITH, B., LO, DF., CHYU, MC., DUNN, D., CHEN, CH., KWUN, IS., 2012.  J. Nutrit. Biochem. 23:1367-77
  42. CHO, S., LEE, DH., WON, CH., KIM, SM., LEE, S., LEE, MJ., CHUNG, JH., 2010. Dermatology 221(2):160-71
  43. SEGGER, D., SCHONLAU, F., 2004. J. Dermatol. Treat. 15(4):222-6
  44. GREUL, AN., GRUNDMANN, JU., HEINRICH, F., PHITZNER, J., BERNHARDT, J., AMBACH, A., BIESALSKI, AK., GAINICK, H., 2002. Skin Pharm. App. Skin Physiol. 15(5):307-15
  45. KISHIMOTO, Y., SAITO, N., KURITA, K., SHIMOKADO, K., MARVYAMA, N., ISHIGAMI, A., Biochem. Biophys. Res. Commun. 2012. 5006-291x(12)62310-8

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